Orana is encountered during Fenris's quest, A Bitter Pill, and is found in the Abandoned Slaver Den. She tells Hawke that Hadriana killed her father using blood magic, explaining that she needed his life for power. Hawke can choose to release Orana; give her gold and tell her to go (Fenris comments that she will be easily robbed); take her back to the Hawke estate as a slave; or hire her as a servant (although she is paid this will result in no loss of gold). If you talk to Orana at the Hawke estate, you do have the option of setting her free (with no loss of gold). You can also set her free and tell her to speak to your mother for help. If you pick this option, your mother tells you that she has sent Orana to the chantry.

If Orana remains with the Hawke family, a lute item can be clicked on in Hawke's room, prompting Hawke to comment that she plays the lute beautifully. Should Hawke romance Merrill, Hawke remarks that she should really just stick to magic. If Hawke is in a romance with Anders, Hawke states that playing the lute is not one of his talents.